ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification
نویسندگان
چکیده
منابع مشابه
ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer.
UNLABELLED Overexpression of ERG in the prostate epithelium, due to chromosomal translocations, contributes to prostate tumorigenesis. Here, genomic analysis of ERG siRNA-treated prostate cells harboring the endogenous TMPRSS2-ERG fusion revealed an inverse relationship between ERG and Annexin A2 (ANXA2) expression at both the RNA and protein level. ANXA2, a Ca(2+)-dependent and phospholipid-bi...
متن کاملERG Rearrangement as a Clonal Expansion Marker for Prostate Cancer
Prostate cancer is the most commonly diagnosed neoplasia and the second most frequent cause of cancer specific death in men in the western civilization. The recent discovery and subsequent characterization of recurrent gene rearrangements of ETS genes – most frequently ERG in the majority of prostate cancers is a milestone in translational prostate cancer research. In this review we summarize t...
متن کاملThe TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis.
BACKGROUND Whether the genomic rearrangement transmembrane protease, serine 2 (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic value in prostate cancer is unclear. METHODS Among men with prostate cancer in the prospective Physicians' Health and Health Professionals Follow-Up Studies, we identified rearrangement status by immunohistochemical assessment of ERG pr...
متن کاملTMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer Progression.
TMPRSS2-Ets gene fusions were identified in prostate cancers where the promoter of transmembrane protease, serine 2 (TMPRSS2) fused with coding sequence of the erythroblastosis virus E26 (Ets) gene family members. TMPRSS2 is an androgen responsive transmembrane serine protease. Ets family members are oncogenic transcription factors that contain a highly conserved Ets DNA binding domain and an N...
متن کامل5′ UTR Control of Native ERG and of Tmprss2:ERG Variants Activity in Prostate Cancer
ERG, a member of the ETS transcription factor family, is frequently overexpressed in prostate cancer as a result of its fusion to the androgen-responsive Tmprss2 gene. Different genomic rearrangements and alternative splicing events around the junction region lead to multiple combination of Tmprss2:ERG fusion transcripts that correlate with different tumor aggressiveness, but their specific fun...
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ژورنال
عنوان ژورنال: Prostate Cancer and Prostatic Diseases
سال: 2010
ISSN: 1365-7852,1476-5608
DOI: 10.1038/pcan.2010.23